Translational Gastroenterology Unit

// people

• Holm Uhlig

  Professor of Paediatric Gastroenterology; Director, Centre for Human Genetics

• Simon Travis

  Professor of Clinical Gastroenterology

• Ahmad Al-Shaibi

  Research specialist; former Uhlig Group member

• Alissa Walsh

  Consultant Gastroenterologist

// projects

• longIBD

  Longitudinal work on inflammatory bowel disease — connecting clinical phenotypes, immune mechanisms, and computational approaches to better understand disease course and classification, with a particular focus on anti–IL-10 IBD. Includes biomarker trajectories, patient-reported outcomes, and related longitudinal measures.

// papers

• Neutralising autoantibodies against IL-10 and HLA-DRB1*01:03 in paediatric patients with inflammatory bowel disease

  Gharahdaghi N., Yeh P.J., Vadakethala K., Coy M., Kabiri L., Naz B., Jayamanne C., Hansson L., Zouboulis V., Rodrigues A., Howarth L., Alqahtani F., Ghate A., Vázquez López F., Green Z., Beattie R.M., Gasparetto M., Nedelkopoulou N., Iyengar A., Gopan A., Croft N.M., Grimaldi C., Kammermeier J., Jones K., Barendregt D.M.H., Chen M., Barnardo M., Zhang Q., Fachal L., Anderson C.A., Adams A., Johnson H., Gordon H., Tal N., Renji E., Wilson D.C., Henderson P., Muhammed R., Lee K.Y., Kapoor A., Levi R., Zilbauer M., Griffiths A.M., Turner D., Hambleton S., Doffinger R., Samsom J.N., UK PIBD BioResource, Parkes M., Travis S.P., Shouval D.S., de Ridder L., Muise A., Snapper S.B., Ashton J.J., Ennis S., Uhlig H.H.

  Gut

  2026 cited 1

• interesting

  Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease

  Gharahdaghi N., Yeh P.J., Ceron-Gutierrez L., Griffin H., Gordon H., Jayamanne C., Fracchia A., Chong A.Y., Walsh A., Brain O., Baker K., Kockelbergh H., Luo Y., Guevara Becerra M., Vadakethala K., Coy M., Kabiri L., Barnardo M., Dunachie S., Kronsteiner B., Adams A., Fowler D., Zhang Q., Fachal L., Anderson C.A., Desoki R., Vestergaard M.V., Larsen L., Wyatt N.J., Lees R.D., Mulligan R.J., Dong C., Sharip M.T., Faustini S.E., Shields A., Pakpoor J., Naz B., Richter A., Satsangi J., Lamb C.A., Parkes M., Powrie F., Mentzer A.J., Sazonovs A., Jess T., Klenerman P., Travis S., Hambleton S., Doffinger R., Uhlig H.H.

  New England Journal of Medicine

  2026 cited 11

• interesting

  Neutralizing Autoantibodies against Interleukin-10 in Inflammatory Bowel Disease

  Griffin H., Ceron-Gutierrez L., Gharahdaghi N., Ebrahimi S., Davies S., Loo P.S., Szabo A., Williams E., Mukhopadhyay A., McLoughlin L., Irwin S., Travis S., Klenerman P., Bunn S., Cant A.J., Hambleton S., Uhlig H.H., Doffinger R.

  New England Journal of Medicine

  2024 cited 61

• interesting

  An Integrated Taxonomy for Monogenic Inflammatory Bowel Disease

  Bolton C., Smillie C.S., Pandey S., Elmentaite R., Wei G., Argmann C., Aschenbrenner D., James K.R., McGovern D., Macchi M., Cho J.H., Shouval D.S., Kammermeier J., Koletzko S., Bagalopal K., Capitani M., Cavounidis A., Pires E., Weidinger C., McCullagh J., Arkwright P.D., Haller W., Siegmund B., Peters L., Jostins L., Travis S., Anderson C.A., Snapper S.B., Klein C., Schadt E.E., Uhlig H.H., et al.

  Gastroenterology

  2021 cited 100