University of Oxford

// departments

• Centre for Human Genetics

  Centre for Human Genetics at the University of Oxford — genetics, immunology, and translational research.

• Nuffield Department of Surgical Sciences

  Academic department of surgery at the University of Oxford — research, clinical innovation, and surgical education.

• Institute of Developmental & Regenerative Medicine

  Institute of Developmental & Regenerative Medicine at the University of Oxford — interdisciplinary research spanning development, regeneration, and translational platforms.

• Oxford Vaccine Group

  Oxford Vaccine Group, Department of Paediatrics — vaccines, infection, and computational biology.

• Translational Gastroenterology Unit

  Translational Gastroenterology Unit — clinical and experimental IBD research within Experimental Medicine / NDM at Oxford.

// labs

• Uhlig Group

  Genetic and immunological mechanisms of intestinal inflammation — paediatric IBD, IEI, and monogenic IBD at the Centre for Human Genetics. Formerly based in the Translational Gastroenterology Unit; ongoing clinical and research ties with TGU.

// people

• Holm Uhlig

  Uhlig Group · Professor of Paediatric Gastroenterology; Director, Centre for Human Genetics

• Calliope Dendrou

  · Associate Professor in Clinical Pathology and Inflammation

• Dan Woodcock

  · Associate Professor of Translational Data Science

• Konstantin C. Zouboulis

  · Researcher, biophysical chemistry

• Alexandra Noble

  Uhlig Group · Postdoctoral scientist

• Pai-Jui Yeh (Charlie)

  Uhlig Group · DPhil student; medical doctor

• Andre Aquime Goncalves

  · Senior Postdoctoral Research Associate in Computational Biology

• Simon Travis

  · Professor of Clinical Gastroenterology

• Ahmad Al-Shaibi

  Uhlig Group · Research specialist; former Uhlig Group member

• Alissa Walsh

  · Consultant Gastroenterologist

• Simon Tautz

  Uhlig Group · Computer science student & entrepreneur

// papers

• Neutralising autoantibodies against IL-10 and HLA-DRB1*01:03 in paediatric patients with inflammatory bowel disease

  Gharahdaghi N., Yeh P.J., Vadakethala K., Coy M., Kabiri L., Naz B., Jayamanne C., Hansson L., Zouboulis V., Rodrigues A., Howarth L., Alqahtani F., Ghate A., Vázquez López F., Green Z., Beattie R.M., Gasparetto M., Nedelkopoulou N., Iyengar A., Gopan A., Croft N.M., Grimaldi C., Kammermeier J., Jones K., Barendregt D.M.H., Chen M., Barnardo M., Zhang Q., Fachal L., Anderson C.A., Adams A., Johnson H., Gordon H., Tal N., Renji E., Wilson D.C., Henderson P., Muhammed R., Lee K.Y., Kapoor A., Levi R., Zilbauer M., Griffiths A.M., Turner D., Hambleton S., Doffinger R., Samsom J.N., UK PIBD BioResource, Parkes M., Travis S.P., Shouval D.S., de Ridder L., Muise A., Snapper S.B., Ashton J.J., Ennis S., Uhlig H.H.

  Gut

  2026 cited 1

• interesting

  Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease

  Gharahdaghi N., Yeh P.J., Ceron-Gutierrez L., Griffin H., Gordon H., Jayamanne C., Fracchia A., Chong A.Y., Walsh A., Brain O., Baker K., Kockelbergh H., Luo Y., Guevara Becerra M., Vadakethala K., Coy M., Kabiri L., Barnardo M., Dunachie S., Kronsteiner B., Adams A., Fowler D., Zhang Q., Fachal L., Anderson C.A., Desoki R., Vestergaard M.V., Larsen L., Wyatt N.J., Lees R.D., Mulligan R.J., Dong C., Sharip M.T., Faustini S.E., Shields A., Pakpoor J., Naz B., Richter A., Satsangi J., Lamb C.A., Parkes M., Powrie F., Mentzer A.J., Sazonovs A., Jess T., Klenerman P., Travis S., Hambleton S., Doffinger R., Uhlig H.H.

  New England Journal of Medicine

  2026 cited 11

• interesting

  An integrated mass spectrometry strategy for quantifying the proteoform diversity of the extensively modified O-glycoprotein Osteopontin

  Zouboulis K.C., Bennett J.L., Daly L.A., Burnap S.A., Holden E., Lutomski C.A., Eyers C.E., Robinson C.V., Struwe W.B., Benesch J.L.P.

  bioRxiv

  2026 cited 0

• interesting

  Measurements of molecular size and shape on a chip

  Zhu X., Bennett T.J.D., Zouboulis K.C.M., Soulias D., Grzybek M., Benesch J.L.P., El-Sagheer A.H., Coskun Ü., Krishnan M.

  Science

  2025 cited 22

• interesting

  Uncovering hidden protein modifications with native top-down mass spectrometry

  Bennett J.L., El-Baba T.J., Zouboulis K.C., Kirschbaum C., Song H., Butroid F.I., Benesch J.L.P., Lutomski C.A., Robinson C.V.

  Nature Methods

  2025 cited 17

• interesting

  Neutralizing Autoantibodies against Interleukin-10 in Inflammatory Bowel Disease

  Griffin H., Ceron-Gutierrez L., Gharahdaghi N., Ebrahimi S., Davies S., Loo P.S., Szabo A., Williams E., Mukhopadhyay A., McLoughlin L., Irwin S., Travis S., Klenerman P., Bunn S., Cant A.J., Hambleton S., Uhlig H.H., Doffinger R.

  New England Journal of Medicine

  2024 cited 61

• interesting

  An Integrated Taxonomy for Monogenic Inflammatory Bowel Disease

  Bolton C., Smillie C.S., Pandey S., Elmentaite R., Wei G., Argmann C., Aschenbrenner D., James K.R., McGovern D., Macchi M., Cho J.H., Shouval D.S., Kammermeier J., Koletzko S., Bagalopal K., Capitani M., Cavounidis A., Pires E., Weidinger C., McCullagh J., Arkwright P.D., Haller W., Siegmund B., Peters L., Jostins L., Travis S., Anderson C.A., Snapper S.B., Klein C., Schadt E.E., Uhlig H.H., et al.

  Gastroenterology

  2021