Uhlig Group

// people

• Holm Uhlig

  Professor of Paediatric Gastroenterology; Director, Centre for Human Genetics

• Alexandra Noble

  Postdoctoral scientist

• Pai-Jui Yeh (Charlie)

  DPhil student; medical doctor

• Simon Tautz

  Computer science student & entrepreneur

// projects

• Knowledge graphs & ML for immune disease classification

  Using knowledge graphs, machine learning, and patient data to uncover patterns in complex biomedical datasets and improve understanding and classification of inborn errors of immunity and inflammatory diseases such as IBD.

• longIBD

  Longitudinal work on inflammatory bowel disease — connecting clinical phenotypes, immune mechanisms, and computational approaches to better understand disease course and classification, with a particular focus on anti–IL-10 IBD. Includes biomarker trajectories, patient-reported outcomes, and related longitudinal measures.

• nanoCITE

  Developing Nanopore sequencing pipelines and computational tools designed to bridge research and clinical practice — making data-driven insights more directly actionable in patient care.

// papers

• interesting

  Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease

  Gharahdaghi N., Yeh P.J., Ceron-Gutierrez L., Griffin H., Gordon H., Jayamanne C., Fracchia A., Chong A.Y., Walsh A., Brain O., Baker K., Kockelbergh H., Luo Y., Guevara Becerra M., Vadakethala K., Coy M., Kabiri L., Barnardo M., Dunachie S., Kronsteiner B., Adams A., Fowler D., Zhang Q., Fachal L., Anderson C.A., Desoki R., Vestergaard M.V., Larsen L., Wyatt N.J., Lees R.D., Mulligan R.J., Dong C., Sharip M.T., Faustini S.E., Shields A., Pakpoor J., Naz B., Richter A., Satsangi J., Lamb C.A., Parkes M., Powrie F., Mentzer A.J., Sazonovs A., Jess T., Klenerman P., Travis S., Hambleton S., Doffinger R., Uhlig H.H.

  New England Journal of Medicine

  2026 cited 2

• interesting

  Neutralizing Autoantibodies against Interleukin-10 in Inflammatory Bowel Disease

  Griffin H., Ceron-Gutierrez L., Gharahdaghi N., Ebrahimi S., Davies S., Loo P.S., Szabo A., Williams E., Mukhopadhyay A., McLoughlin L., Irwin S., Travis S., Klenerman P., Bunn S., Cant A.J., Hambleton S., Uhlig H.H., Doffinger R.

  New England Journal of Medicine

  2024 cited 52