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Building databases for Uhlig Lab

2025 active

Designing and building research databases for the Uhlig Lab, with a focus on anti–IL-10 IBD cohorts and related clinical–molecular data.

databases IBD IL-10 autoantibodies clinical data

Active since 2025: building structured databases for the Uhlig Lab at Oxford — capturing clinical phenotypes, assays, and molecular annotations with particular attention to anti–IL-10 autoantibody–mediated IBD.

// people

// relevant papers

  • interesting

    Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease

    Gharahdaghi N., Yeh P.J., Ceron-Gutierrez L., Griffin H., Gordon H., Jayamanne C., Fracchia A., Chong A.Y., Walsh A., Brain O., Baker K., Kockelbergh H., Luo Y., Guevara Becerra M., Vadakethala K., Coy M., Kabiri L., Barnardo M., Dunachie S., Kronsteiner B., Adams A., Fowler D., Zhang Q., Fachal L., Anderson C.A., Desoki R., Vestergaard M.V., Larsen L., Wyatt N.J., Lees R.D., Mulligan R.J., Dong C., Sharip M.T., Faustini S.E., Shields A., Pakpoor J., Naz B., Richter A., Satsangi J., Lamb C.A., Parkes M., Powrie F., Mentzer A.J., Sazonovs A., Jess T., Klenerman P., Travis S., Hambleton S., Doffinger R., Uhlig H.H.

    New England Journal of Medicine

    Neutralizing anti–IL-10 autoantibodies in ~3.5% of IBD patients, strongly linked to HLA-DRB1*01:03 — extending the phenocopy story from rare infantile cases into adult IBD cohorts.

    2026 cited 2

  • interesting

    Neutralizing Autoantibodies against Interleukin-10 in Inflammatory Bowel Disease

    Griffin H., Ceron-Gutierrez L., Gharahdaghi N., Ebrahimi S., Davies S., Loo P.S., Szabo A., Williams E., Mukhopadhyay A., McLoughlin L., Irwin S., Travis S., Klenerman P., Bunn S., Cant A.J., Hambleton S., Uhlig H.H., Doffinger R.

    New England Journal of Medicine

    Neutralizing anti–IL-10 autoantibodies as a phenocopy of inborn errors of IL-10 signalling in infantile-onset IBD — with therapeutic implications for B-cell depletion.

    2024 cited 52